Official website · Licensed SciatiEase retailer
SciatiEase is a capsule dietary supplement sold for sciatic nerve comfort. One serving is 4 capsules a day, often split 2 with breakfast and 2 with dinner. Each serving lists PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg, benfotiamine 200 mg, four B vitamins and a 50 mg herb blend. Single ingredients have small trials; SciatiEase itself has none.
Written by the SciatiEase label desk · Updated
From $49.99 a bottle
One serving, along a nerve fiber
Drawing, not dataA capsule opens into 12 dots, one per label line, beside a nerve fiber where a signal hops from gap to gap. It shows what the label lists, not what reaches your nerves or what it does there.
Dose check, 4 capsules
12label lines
| Form | Gelatin capsules, white bottle |
|---|---|
| Size | 120 capsules, 30 servings |
| Serving | 4 capsules a day |
| Biggest amounts | PEA 500 mg, R-ALA 250 mg |
| Maker | SciatiEase Labs |
| Price | From $49.99 a bottle |
| Guarantee | 180 days, money back |
What it is01
SciatiEase is a dietary supplement in capsules, made by SciatiEase Labs and sold for sciatic nerve comfort. It is not a pain medicine and not a treatment for sciatica.
The bottle holds 120 capsules. The Supplement Facts panel sets one serving at 4 capsules, so a bottle lasts 30 days at the full serving or 60 days at 2 a day. The front reads "Supports Sciatic Nerve Health*", and the asterisk points to the standard FDA statement for supplements (FDA, Using Dietary Supplements).
Inside are 12 ingredients, which matches the "12 Research Backed" badge on the front. Eight have printed amounts. The four herbs share a 50 mg blend whose single amounts are hidden, which the rules allow as long as the blend lists them from most to least by weight (21 CFR 101.36 (eCFR)).
Sciatica itself is a symptom, not a disease: leg pain, tingling or numbness from pressure on the sciatic nerve or its roots, often from a disc (MedlinePlus, Sciatica). Most cases improve with time and activity, though about 20-30% of people still have trouble a year or two later (Koes et al., BMJ 2007). A capsule cannot move a disc, so the fair question is whether these nutrients can ease symptoms around that process.
Claims vs evidence02
No. The sales page blames "sciatic nerve starvation" and promises a fix, but no study has tested SciatiEase, and no supplement is proven to bring nerve cells back.
The article-style sales page leans on strong lines and gives no sources for them. We list each one in quotes, next to what the research says.
The bottle itself is more careful. Its claims are "support" claims with an asterisk, which is the wording the law allows for supplements without FDA review.
Claims as printed on the sales page (SciatiEase sales page) and the bottle. Health claims need competent and reliable scientific evidence, generally human trials of the same product (FTC, Health Products Compliance Guidance).
Do not stop, skip or cut a pain medicine, nerve medicine or blood thinner because you started a supplement. Talk to the doctor who prescribed it first. More detail on side effects and interactions.
How you take it03
Take 4 capsules a day with food: 2 with breakfast and 2 with dinner. That is one serving on the Supplement Facts panel, and the most you should take in a day.
The sales page starts readers on 2 capsules with breakfast and adds 2 with dinner "for more" (SciatiEase sales page). The brand's order page also suggests going up to 4 in the morning and 4 at night if nothing changes in 14 days (SciatiEase order page). We do not repeat that advice: it is twice the serving on the panel, and it would double the vitamin B6 to 40 mg a day.
One serving is 4 capsules. Check the side of your bottle for its warning text, and show the panel to your doctor or pharmacist.
Swallow them with water and food. The sales page starts the day this way; food tends to settle the stomach.
That completes the 4-capsule serving. Keep any prescribed medicine on its usual schedule.
Note how far you walk and how you sleep. The guarantee runs 180 days from purchase.
Four capsules make one serving, and the bottle holds 30 servings. Taken with meals, the capsules tend to sit better on the stomach, and alpha-lipoic acid in particular can cause nausea in some people (Linus Pauling Institute, Lipoic Acid). The full routine, with a 24-hour dial, sits on the how to take it page.
Ingredients04
Twelve label lines: four B vitamins, the 750 mg AlphaPalm blend of R-ALA and PEA, acetyl-L-carnitine, benfotiamine and a 50 mg blend of four herbs.
PEA (palmitoylethanolamide) is the largest single amount at 500 mg per serving. It is a fat-based compound the body makes and uses to calm pain and inflammation signals. R-alpha lipoic acid adds 250 mg of an antioxidant studied in diabetic nerve damage.
The B vitamins come in their "active" coenzyme forms: B2 as riboflavin-5-phosphate, B6 as pyridoxal-5-phosphate, folate as 5-MTHF and B12 as methylcobalamin. With a gelatin capsule shell, the product is not vegetarian.
From the Supplement Facts panel. Places 1-4 of the herbal blend are listed from most to least by weight (21 CFR 101.36 (eCFR)). The other ingredients (gelatin capsule, cellulose, vegetable stearate, silica) are left out of the count.
500 mgThe largest single amount on the label
A fatty acid amide the body makes; part of the endocannabinoid-like signaling family
Evidence: Small, mostly short trials suggest less pain; quality varies500 mg per 4 capsules
Studied at300-1,200 mg a day across 11 pain trials; 300 or 600 mg a day in one sciatica trial
Watch forWell tolerated in studies; long-term data are thin.
Full profile
250 mgHalf of the AlphaPalm blend's partner pair
The natural R form of alpha-lipoic acid, an antioxidant made in the body
Evidence: Small symptom gains in diabetic neuropathy; not tested in sciatica250 mg per 4 capsules
Studied at600 mg a day of standard (R plus S) ALA in diabetic nerve trials
Watch forMay lower blood sugar; stomach upset; rare low-sugar reactions.
Full profile
250 mgPrinted amount, no % Daily Value
An acetylated form of carnitine, which helps cells burn fat for energy
Evidence: Very low-certainty evidence for some pain relief in diabetic neuropathy250 mg per 4 capsules
Studied at1,500-3,000 mg a day in diabetic neuropathy trials; little effect at 1,500 mg or less
Watch forIn one large trial it made chemotherapy nerve damage worse; about 3 g a day can upset the stomach and cause a fishy odor.
Full profile
200 mgA fat-soluble vitamin B1
A fat-soluble form of vitamin B1 (thiamin)
Evidence: Mixed: one small trial helped, a longer one did not200 mg per 4 capsules
Studied at300-600 mg a day in diabetic neuropathy trials
Watch forGenerally well tolerated; little long-term safety data.
Full profile
1,000 mcgThe biggest % Daily Value on the panel
Cobalamin in its methyl coenzyme form
Evidence: Helps if you are low in B12; little proof otherwise1000 mcg per 4 capsules (41,667% DV)
Studied at2.4 mcg a day meets adult needs; 1,000-2,000 mcg a day orally to correct a deficiency
Watch forVery low toxicity; metformin and acid reducers can lower B12 levels.
Full profile
20 mgThree B vitamins in active forms
Vitamin B2, Vitamin B6, Folate
Evidence: Limited; see each lineVitamin B2 25 mg; Vitamin B6 20 mg; Folate 500 mcg DFE
Studied atDoses vary; see the page
Watch forHarmless bright yellow urine; no upper limit set.
Full profile
Up to 50 mgFirst of four in the 50 mg herbal blend
Daisy-family herb, flower extract
Evidence: Mixed for migraine; none for sciaticaNot listed; #1 of 4 in the 50 mg herbal blend, so at most 50 mg per serving
Studied atStudied for migraine prevention, not nerve pain
Watch forAvoid in pregnancy; ragweed allergy; may add to blood thinners.
Full profile
Up to 25 mgPlaces 2, 3 and 4 of the herbal blend
Passionflower, Chinese skullcap, Oat straw
Evidence: Limited; see each linePassionflower at most 25 mg; Chinese skullcap at most 16.7 mg; Oat straw at most 12.5 mg
Studied atDoses vary; see the page
Watch forDrowsiness; may add to sedatives.
Full profileThe brand home page lists larger amounts for four ingredients (PEA 600 mg, R-ALA 300 mg, ALCAR 300 mg, benfotiamine 300 mg) (SciatiEase order page). The Supplement Facts panel prints the lower figures, and the panel is what we follow. See the supplement facts page.
The label05
Eleven numbered spots on the Supplement Facts panel and seven on the bottle front. Tap a number to read that part in plain words.
The panel and the front tell two different stories. The panel is the legal record of what is in a serving. The front is marketing, held to looser rules, so "Maximum Strength" and "Research Backed" are phrases with no fixed meaning.
Tap a number to read that part of the panel.
4 capsules per serving and 30 servings: 120 capsules, a 30-day bottle at the full serving.
25 mg as riboflavin-5-phosphate, 1,923% of the Daily Value. Adults need about 1.1-1.3 mg a day.
20 mg as P5P, 1,177% DV. Under the 100 mg upper limit, but high B6 over time can harm nerves.
500 mcg DFE as 5-MTHF, 120% DV: close to everyday needs.
1 mg (1,000 mcg) as methylcobalamin, 41,667% DV. The body absorbs only a small share of a big dose.
Unlike most blends, both amounts are printed: R-ALA 250 mg and PEA 500 mg.
250 mg. Neuropathy trials used 1,500-3,000 mg a day.
200 mg of this fat-soluble vitamin B1. Trials used 300-600 mg a day.
Feverfew, passionflower, Chinese skullcap and oat straw, all 4:1 extracts. Single amounts are hidden.
The double dagger means no Daily Value exists for that ingredient.
Gelatin capsule, microcrystalline cellulose, vegetable stearate, silica. Gelatin means not vegetarian.
The photo below is the bottle the brand ships. Its renders print "Sciatic Nerve Formula*" where this photo prints "Supports Sciatic Nerve Health*", so packaging may vary between batches.
Tap a number to read that part of the bottle.
'SciatiEase Labs' on the blue band. The brand site names SciatiEase Labs, LLC of Smyrna, Tennessee.
There is no legal standard for this phrase. Several amounts sit below the doses used in studies.
SciatiEase, with a registered-mark symbol.
'Supports Sciatic Nerve Health*': a structure/function claim. The asterisk points to the FDA statement.
'12 Research Backed Herbs, Vitamins, & Antioxidants'. The panel has 12 lines; the research is on single ingredients.
Supports Comfort, Nerve Health and a Healthy Inflammatory Response, each with an asterisk.
'120 Capsules Dietary Supplement' on the side strip.
Dose vs research06
Some are, some are not. PEA and B12 reach the low end of what trials used. Acetyl-L-carnitine and benfotiamine sit well below it.
A dose match does not prove a product works, but a big shortfall makes a benefit less likely. Acetyl-L-carnitine is the clearest gap: trials in diabetic nerve pain used 1,500-3,000 mg a day, and at 1,500 mg or less there was little difference from placebo (Rolim et al., Cochrane 2019). SciatiEase has 250 mg.
For R-alpha lipoic acid the comparison is less direct. Every human study used standard ALA, a half-and-half mix of the R and S forms, usually at 600 mg a day (Linus Pauling Institute, Lipoic Acid). That holds about 300 mg of the R form, close to the 250 mg here.
| Ingredient | Evidence | What it found |
|---|---|---|
| PEA | Meta-analysis, 11 trials, 774 people (Lang-Illievich et al., Nutrients 2023) | Lower pain scores at 300-1,200 mg a day; no major side effects; trials varied in quality |
| PEA in sciatica | One trial, 636 people, 3 weeks (Keppel Hesselink, J Pain Res 2015) | More people reached 50% pain relief at 600 mg a day than at 300 mg |
| Alpha-lipoic acid | Meta-analysis (Mijnhout et al., Int J Endocrinol 2012) | Fewer diabetic nerve symptoms, mostly with IV doses; oral benefit less certain |
| Acetyl-L-carnitine | Cochrane review (Rolim et al., Cochrane 2019) | Very low-certainty pain relief at 1,500-3,000 mg a day |
| Benfotiamine | One 6-week trial (Stracke et al., BENDIP 2008) | A borderline result at 300-600 mg a day |
Bottle claims07
The bottle makes four support claims, each with the FDA asterisk. Here is each one next to what studies of the ingredients found.
A "support" claim describes how a nutrient affects the body's normal structure or function. It does not need FDA approval, but the seller must have evidence and must print the FDA disclaimer (FDA, Using Dietary Supplements).
The bottle says“Supports Sciatic Nerve Health*”
What the evidence saysNo trial of the product. PEA showed pain drops in short trials, one in sciatica at 300 or 600 mg a day; R-ALA and ALCAR were studied in diabetic nerve damage, not sciatica. (Keppel Hesselink, J Pain Res 2015) (Mijnhout et al., Int J Endocrinol 2012) (Rolim et al., Cochrane 2019)
The bottle says“Supports Comfort*”
What the evidence saysPEA has the most comfort-related data among the 12 lines. Reviews call the evidence promising but limited by small, varied trials. (Lang-Illievich et al., Nutrients 2023) (Nestmann, Food Sci Nutr 2017)
The bottle says“Supports Nerve Health*”
What the evidence saysB12 helps nerves if you are low in it. B6 is needed too, but too much B6 over time can harm nerves; 20 mg a serving is under the 100 mg limit. (NIH ODS, Vitamin B12) (NIH ODS, Vitamin B6) (TGA, Vitamin B6 and neuropathy)
The bottle says“Supports Healthy Inflammatory Response*”
What the evidence saysPEA and feverfew act on inflammation pathways in lab work. No study measured inflammation in people taking SciatiEase. (Lang-Illievich et al., Nutrients 2023) (NCCIH, Feverfew)
Claims as printed on the bottle front (photo); the asterisks point to the FDA statement (FDA, Using Dietary Supplements).
Safety08
Anyone on a blood thinner, diabetes medicine or chemotherapy, anyone pregnant or nursing, and anyone with warning signs like groin numbness or new bladder trouble.
Most people in the PEA and ALA trials had mild side effects or none (Lang-Illievich et al., Nutrients 2023) (Linus Pauling Institute, Lipoic Acid). The bigger questions are interactions and the 20 mg of vitamin B6. The US upper limit is 100 mg a day, yet Australia's regulator has linked nerve symptoms to B6 even below 50 mg and now requires a warning on products above 10 mg a day (NIH ODS, Vitamin B6) (TGA, Vitamin B6 and neuropathy).
Six questions follow. A yes means a talk with your doctor or pharmacist first, or extra care at home.
Not on this list. Ask your pharmacist; the list is not complete.
No direct interaction with the label ingredients is listed in the sources we checked. Passionflower and skullcap may add to the drowsiness these medicines cause. Pregabalin did no better than placebo for sciatica in one large trial, which is worth discussing with your doctor; do not stop either drug on your own. (NCCIH, Passionflower) (Mathieson et al., NEJM 2017 (PRECISE))
Feverfew and Chinese skullcap may slow clotting and add to bleeding risk. The Eliquis label asks you to tell your doctor about every supplement. Ask your prescriber before you start. (MSKCC, Feverfew) (MSKCC, Scutellaria baicalensis) (MedlinePlus, Apixaban)
Alpha-lipoic acid may lower blood sugar and add to diabetes drugs. Metformin can lower B12 over time, which the 1,000 mcg of B12 may offset; your doctor can check your level. (Linus Pauling Institute, Lipoic Acid) (NIH ODS, Vitamin B12) (Vallianou et al., Metabol Open 2026)
Chinese skullcap lowered rosuvastatin levels in a small study of volunteers. Ask your pharmacist if you take a statin. (MSKCC, Scutellaria baicalensis)
Acetyl-L-carnitine made chemotherapy nerve damage worse in one large trial, and antioxidants during treatment should be cleared with your cancer team. (Hershman et al., J Clin Oncol 2013)
Passionflower and Chinese skullcap may add to drowsiness. Avoid driving until you know how you react. (NCCIH, Passionflower) (MSKCC, Scutellaria baicalensis)
Vitamin B6 interacts with some seizure medicines, and valproate, phenytoin and similar drugs lower carnitine levels, according to NIH. Ask your neurologist first. (NIH ODS, Vitamin B6) (NIH ODS, Carnitine)
NSAIDs and feverfew both affect platelets, so bleeding risk may add up, especially with a blood thinner. NSAIDs gave only a small benefit for sciatica in trials. (MSKCC, Feverfew) (Rasmussen-Barr et al., Cochrane 2016)
A short list built from NIH, MSKCC and trial sources, not a full interaction check. Bring the bottle or the Supplement Facts panel to your pharmacist. Keep taking prescribed medicine.
When to get help09
Numbness in the groin or inner thighs, new trouble with the bladder or bowels, or leg weakness that keeps getting worse need emergency care the same day.
Those signs can point to cauda equina syndrome, where the bundle of nerve roots at the base of the spine is squeezed. Surgery within 48 hours of the first symptoms gives a clear advantage for recovery (AANS, Cauda Equina Syndrome). No supplement belongs in that plan.
Most casesMost sciatica improves over weeks with time, staying active and simple self-care. See your doctor if pain is severe, lasts more than a few weeks or keeps coming back.
Call 911Or go to the emergency room for saddle numbness, new bladder or bowel problems, or fast-worsening leg weakness. These can mean cauda equina syndrome, which needs care within hours.
Signs from AANS and NHS-style guidance (AANS, Cauda Equina Syndrome) and MedlinePlus (MedlinePlus, Sciatica). A supplement is never a reason to wait.
For everyday sciatica, guidelines put staying active and exercise first (NICE NG59, Low back pain and sciatica). Read sciatica basics and relief options.
Weighing it up10
A clear, mostly printed label with a real PEA dose, against no product trial, low carnitine and a sales page that overstates the case.
Our view: SciatiEase is a reasonable thing to discuss with your doctor if you want to try PEA, and a poor reason to delay care or change a prescription.
Prices11
$69.00 for one bottle plus $6.95 shipping, $59.99 a bottle for three and $49.99 a bottle for six, with free US shipping on the bigger packs.
At the full serving, a bottle lasts 30 days, so the daily cost runs from about $2.30 on one bottle to about $1.67 on the 6-pack. At 2 capsules a day those figures halve. The checkout shows the final total, including any tax.
Try it
$69.00a bottle
plus $6.95 shipping
+$6.95 shipping
Free US shipping
$59.99a bottle
Total $179.97 · $59.99 a bottle
Free US shipping
Lowest per bottle
$49.99a bottle
Total $299.94 · $49.99 a bottle
Free US shipping
Prices on the SciatiEase order page, October 18, 2026 (SciatiEase order page). One bottle adds $6.95 shipping; the brand lists free US shipping on 3 and 6. Totals are the bottle price times the bottles, and the checkout shows the final figure. Per-day costs use 30 days a bottle at 4 capsules and 60 at 2. We never show the struck "regular" prices or the "You Save" lines.
You need 3 bottles. The 3-bottle pack covers it for $179.97 ($59.99 a bottle), with free US shipping.
Uses the order-page prices: $69.00 for 1 bottle plus $6.95 shipping, $59.99 a bottle for 3 and $49.99 a bottle for 6. Bottle icons fill one per bottle. A planning aid only; the checkout shows the final total.
Order buttons go to the SciatiEase sales page, where these prices and the guarantee apply (SciatiEase order page). We know of no other authorized store; see where to buy for Amazon, Walmart and CVS.
Guarantee12
The order page promises a 100% refund within 180 days of purchase. You call the desk with your order ID and mail the bottles back with tracking.
Refunds post 3-5 business days after the bottles are credited, then take 5-10 days to show on your card. Return shipping is on you.
Keep the order ID, because the desk asks for it. The 180 days count from the date of purchase.
Note how far you walk, how you sleep and how often pain wakes you. Keep your prescribed medicine going the whole time.
Call +1 (844) 361-1273 with your order ID before day 180, or use the support form on sciatiease.com.
Send the bottles to the return address the desk gives you, with your full name, email and order ID. Return postage is on you.
One answer in the brand's FAQ mentions a full year, minus shipping, so ask the desk which terms apply to your order. Read the guarantee and the refund policy.
Reviews13
A review goes up only once it is matched to a real order and the buyer agrees. None is verified yet, so the cards below are open slots.
The vendor supplied customer photos, and each card shows one small. The names, ratings and stories in the seller's sample copy are not verified, so they stay out. The FTC bans fake reviews and testimonials (FTC, Final rule on fake reviews).
4.4out of 5
Based on 818 verified ratings
Filled in only from reviews matched to a real order. How we check reviews.
I work from the kitchen table. Heating pad still on the chair. I use it less. I don't write miracle stories. I keep it on the bleacher tote. I take it after I pack the lunch.
Pack review 1, as supplied · Photo supplied by the vendor
I travel for installs. Dog walk around the block. That's my test. Not a wheelchair pitch. I keep it by the hymnals. I take it before I walk the mall.
Pack review 2, as supplied · Photo supplied by the vendor
I teach, then I commute. I take pain tablets the clinic prescribed. Showed this bottle. They said keep theirs. I keep it in the tackle box. I take it before league night.
Pack review 3, as supplied · Photo supplied by the vendor
See how we check reviews and our look at whether SciatiEase is legit.
Badges and photos14
One brand seal and five front-of-bottle phrases, plus the brand's product photos, each with what it does and does not prove.
None of the material we could read names a factory audit or a GMP certificate. The brand site says the components are made in Tampa, Florida, and that orders ship from Florida (SciatiEase order page).
Matches the order page's 180-day guarantee. Return shipping is on the buyer.
Printed above the name. There is no standard for this phrase, and the amounts sit below most study doses.
Twelve lines are on the panel. Research exists for single ingredients, not for SciatiEase itself.
A structure/function claim with the FDA asterisk. It is not a treatment claim.
Another asterisked support claim. No trial of the product measured inflammation.
The brand site's wording. No facility name, audit or GMP certificate is published.
One badge image comes from the brand; the rest are words printed on the bottle or the brand site. A badge or a phrase is a claim by the seller, not a certificate. FDA does not approve supplements before they are sold (FDA, Using Dietary Supplements), and health claims in ads need real evidence (FTC, Health Products Compliance Guidance).
Product images from the brand. They show packaging, not outcomes. (SciatiEase order page)
Computer renders. They print 'Sciatic Nerve Formula*' where the bottle photo prints 'Supports Sciatic Nerve Health*'. (SciatiEase order page)
Brand graphics. A seal or a logo row is a seller claim, not a certificate. (SciatiEase order page)
SciatiEase is made by SciatiEase Labs. Sciatiease, which runs this site, is a licensed SciatiEase retailer, not the maker, and earns money from our order links. Lot code SE-26/SC-6243 is a seller reference, not lab proof. Read about us and testing and quality.
FAQ15
No question matches. Try another word.
A capsule dietary supplement made by SciatiEase Labs and sold for sciatic nerve comfort. One serving is 4 capsules, a bottle holds 120, and each serving lists PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg, benfotiamine 200 mg, four B vitamins and a 50 mg herb blend.
Nobody has tested SciatiEase itself. PEA, its largest ingredient, lowered pain scores in small trials, including one in sciatica (Lang-Illievich et al., Nutrients 2023) (Keppel Hesselink, J Pain Res 2015). Other doses, like acetyl-L-carnitine, sit far below what studies used (Rolim et al., Cochrane 2019). Treat it as an experiment, not a treatment.
No direct interaction with the label ingredients appears in the sources we checked, but passionflower and skullcap may add to drowsiness (NCCIH, Passionflower). Ask your doctor or pharmacist first, and do not stop or change gabapentin on your own.
Ask your prescriber first. Feverfew and Chinese skullcap may add to bleeding risk with blood thinners (MSKCC, Feverfew) (MSKCC, Scutellaria baicalensis), and the Eliquis label asks you to report every supplement (MedlinePlus, Apixaban). Keep taking Eliquis exactly as prescribed.
Four, per the Supplement Facts panel: one serving. The sales page splits it into 2 with breakfast and 2 with dinner (SciatiEase sales page). Do not take more than 4 a day, even though the brand's order page suggests more if nothing changes in two weeks.
No. The FDA does not approve dietary supplements before they are sold, and the bottle's claims carry the standard FDA disclaimer (FDA, Using Dietary Supplements). FDA approval applies to drugs, not to supplements like this one.
One bottle is $69.00 plus $6.95 shipping. Three bottles are $59.99 each and six are $49.99 each, with free US shipping on both. At 4 capsules a day that works out to about $2.30, $2.00 or $1.67 a day.
The SciatiEase label desk writes them. A medical reviewer has not been named yet. The box at the bottom of each page shows where those details will go once a review is on file.
Licensed SciatiEase retailer
Look over your medicines first, then choose a pack. Three or six bottles ship free in the US and cost less per bottle, and the 180-day guarantee covers every pack.
