Ingredients
SciatiEase Ingredients: What Is in Each 4-Capsule Serving?
SciatiEase ingredients are 12 label lines per 4-capsule serving: vitamins B2, B6, folate and B12, R-alpha lipoic acid 250 mg, PEA 500 mg, acetyl-L-carnitine 250 mg, benfotiamine 200 mg and a 50 mg blend of four herbs. PEA has the most relevant research. No study has tested the full formula.
Written by the SciatiEase label deskUpdated
The list01
What are the ingredients in SciatiEase?
Twelve lines in four groups: B vitamins, the AlphaPalm pair, carnitine and a herbal blend.
Eight lines carry a printed amount. The four herbs share one 50 mg total.
- 1Vitamin B2 (riboflavin-5-Phosphate)25 mg per 4 capsules · 1,923% DV
- 2Vitamin B6 (pyridoxal-5-phosphate)20 mg per 4 capsules · 1,177% DV
- 3Folate (5-methyltetrahydrofolate)500 mcg DFE per 4 capsules · 120% DV
- 4Vitamin B12 (methylcobalamin)1,000 mcg per 4 capsules · 41,667% DV
- 5R-Alpha Lipoic Acid (R-ALA)250 mg per 4 capsules
- 6Palmitoylethanolamide (PEA)500 mg per 4 capsules
- 7Acetyl-L-carnitine (ALCAR)250 mg per 4 capsules
- 8Benfotiamine200 mg per 4 capsules
- 9Feverfew (Tanacetum parthenium flower) extract 4:1Herbal blend place 1 · at most 50 mg
- 10Passionflower (Passiflora incarnata) extract 4:1Herbal blend place 2 · at most 25 mg
- 11Chinese Skullcap (root) extract 4:1Herbal blend place 3 · at most 16.7 mg
- 12Oat Straw extract 4:1Herbal blend place 4 · at most 12.5 mg
From the Supplement Facts panel. Places 1-4 of the herbal blend are listed from most to least by weight (21 CFR 101.36 (eCFR)). The other ingredients (gelatin capsule, cellulose, vegetable stearate, silica) are left out of the count.
Doses02
Are SciatiEase ingredient doses as high as the studies used?
PEA and B12 reach study ranges. Carnitine and benfotiamine fall short.
A matching dose does not prove a benefit, but a big gap makes one less likely.
| Label line | Where on the label | Per 4 capsules | Per 2 capsules | Amount used in research | Evidence |
|---|---|---|---|---|---|
| Vitamin B2 (riboflavin-5-Phosphate) | Printed line | 25 mg (1,923% DV) | 12.5 mg | 1.1-1.3 mg a day meets adult needs; 400 mg a day in migraine studies (NIH ODS, Riboflavin) | No nerve-pain trials |
| Vitamin B6 (pyridoxal-5-phosphate) | Printed line | 20 mg (1,177% DV) | 10 mg | 1.3-1.7 mg a day meets adult needs; upper limit 100 mg a day (NIH ODS, Vitamin B6) (TGA, Vitamin B6 and neuropathy) | No benefit for nerve pain shown; too much can harm nerves |
| Folate (5-methyltetrahydrofolate) | Printed line | 500 mcg DFE (120% DV) | 250 mcg DFE | 400 mcg DFE a day meets adult needs (NIH ODS, Folate) | Needed for nerves; no nerve-pain trials of this dose |
| Vitamin B12 (methylcobalamin) | Printed line | 1,000 mcg (41,667% DV) | 500 mcg | 2.4 mcg a day meets adult needs; 1,000-2,000 mcg a day orally to correct a deficiency (NIH ODS, Vitamin B12) (Ang et al., Cochrane 2008) | Helps if you are low in B12; little proof otherwise |
| R-Alpha Lipoic Acid (R-ALA) | AlphaPalm Blend, amount printed | 250 mg | 125 mg | 600 mg a day of standard (R plus S) ALA in diabetic nerve trials (Linus Pauling Institute, Lipoic Acid) (Mijnhout et al., Int J Endocrinol 2012) | Small symptom gains in diabetic neuropathy; not tested in sciatica |
| Palmitoylethanolamide (PEA) | AlphaPalm Blend, amount printed | 500 mg | 250 mg | 300-1,200 mg a day across 11 pain trials; 300 or 600 mg a day in one sciatica trial (Lang-Illievich et al., Nutrients 2023) (Keppel Hesselink, J Pain Res 2015) (Nestmann, Food Sci Nutr 2017) | Small, mostly short trials suggest less pain; quality varies |
| Acetyl-L-carnitine (ALCAR) | Printed line | 250 mg | 125 mg | 1,500-3,000 mg a day in diabetic neuropathy trials; little effect at 1,500 mg or less (Rolim et al., Cochrane 2019) (Hershman et al., J Clin Oncol 2013) (NIH ODS, Carnitine) | Very low-certainty evidence for some pain relief in diabetic neuropathy |
| Benfotiamine | Printed line | 200 mg | 100 mg | 300-600 mg a day in diabetic neuropathy trials (NIH ODS, Thiamin) (Stracke et al., BENDIP 2008) | Mixed: one small trial helped, a longer one did not |
| Feverfew (Tanacetum parthenium flower) extract 4:1 | #1 of 4 in the 50 mg herbal blend | at most 50 mg | at most 25 mg | Studied for migraine prevention, not nerve pain (NCCIH, Feverfew) (MSKCC, Feverfew) | Mixed for migraine; none for sciatica |
| Passionflower (Passiflora incarnata) extract 4:1 | #2 of 4 in the 50 mg herbal blend | at most 25 mg | at most 12.5 mg | Studied for anxiety and sleep (NCCIH, Passionflower) | Limited; none for nerve pain |
| Chinese Skullcap (root) extract 4:1 | #3 of 4 in the 50 mg herbal blend | at most 16.7 mg | at most 8.3 mg | No studied dose for nerve pain found (MSKCC, Scutellaria baicalensis) | Lab and animal studies only |
| Oat Straw extract 4:1 | #4 of 4 in the 50 mg herbal blend | at most 12.5 mg | at most 6.2 mg | Small studies on attention and mood (Kennedy et al., Nutrients 2020) | Very limited |
Profiles03
What do the SciatiEase active ingredients do?
Each card gives the amount, the studied dose and the main caution.
PEA has the only trial in sciatica (Keppel Hesselink, J Pain Res 2015).
-
500 mg01PEA (palmitoylethanolamide)
The largest single amount on the label
A fatty acid amide the body makes; part of the endocannabinoid-like signaling family
Evidence: Small, mostly short trials suggest less pain; quality variesPer 4 capsules500 mg per 4 capsules
Studied at300-1,200 mg a day across 11 pain trials; 300 or 600 mg a day in one sciatica trial
Watch forWell tolerated in studies; long-term data are thin.
Full profile -
250 mg02R-alpha lipoic acid
Half of the AlphaPalm blend's partner pair
The natural R form of alpha-lipoic acid, an antioxidant made in the body
Evidence: Small symptom gains in diabetic neuropathy; not tested in sciaticaPer 4 capsules250 mg per 4 capsules
Studied at600 mg a day of standard (R plus S) ALA in diabetic nerve trials
Watch forMay lower blood sugar; stomach upset; rare low-sugar reactions.
Full profile -
250 mg03Acetyl-L-carnitine
Printed amount, no % Daily Value
An acetylated form of carnitine, which helps cells burn fat for energy
Evidence: Very low-certainty evidence for some pain relief in diabetic neuropathyPer 4 capsules250 mg per 4 capsules
Studied at1,500-3,000 mg a day in diabetic neuropathy trials; little effect at 1,500 mg or less
Watch forIn one large trial it made chemotherapy nerve damage worse; about 3 g a day can upset the stomach and cause a fishy odor.
Full profile -
200 mg04Benfotiamine
A fat-soluble vitamin B1
A fat-soluble form of vitamin B1 (thiamin)
Evidence: Mixed: one small trial helped, a longer one did notPer 4 capsules200 mg per 4 capsules
Studied at300-600 mg a day in diabetic neuropathy trials
Watch forGenerally well tolerated; little long-term safety data.
Full profile -
1,000 mcg05Vitamin B12 (methylcobalamin)
The biggest % Daily Value on the panel
Cobalamin in its methyl coenzyme form
Evidence: Helps if you are low in B12; little proof otherwisePer 4 capsules1000 mcg per 4 capsules (41,667% DV)
Studied at2.4 mcg a day meets adult needs; 1,000-2,000 mcg a day orally to correct a deficiency
Watch forVery low toxicity; metformin and acid reducers can lower B12 levels.
Full profile -
20 mg06Vitamin B6, B2 and folate
Three B vitamins in active forms
Vitamin B2, Vitamin B6, Folate
Evidence: Limited; see each linePer 4 capsulesVitamin B2 25 mg; Vitamin B6 20 mg; Folate 500 mcg DFE
Studied atDoses vary; see the page
Watch forHarmless bright yellow urine; no upper limit set.
Full profile -
Up to 50 mg07Feverfew
First of four in the 50 mg herbal blend
Daisy-family herb, flower extract
Evidence: Mixed for migraine; none for sciaticaPer 4 capsulesNot listed; #1 of 4 in the 50 mg herbal blend, so at most 50 mg per serving
Studied atStudied for migraine prevention, not nerve pain
Watch forAvoid in pregnancy; ragweed allergy; may add to blood thinners.
Full profile -
Up to 25 mg08Passionflower, skullcap and oat straw
Places 2, 3 and 4 of the herbal blend
Passionflower, Chinese skullcap, Oat straw
Evidence: Limited; see each linePer 4 capsulesPassionflower at most 25 mg; Chinese skullcap at most 16.7 mg; Oat straw at most 12.5 mg
Studied atDoses vary; see the page
Watch forDrowsiness; may add to sedatives.
Full profile
Vitamins04
Which vitamin ingredients are in SciatiEase?
B2, B6, folate and B12 in active forms, plus benfotiamine, a form of vitamin B1.
A Cochrane review found too little evidence to say whether B vitamins help nerve pain (Ang et al., Cochrane 2008). The 20 mg of B6 sits above Australia's 10 mg warning line (TGA, Vitamin B6 and neuropathy), so count other B6 sources.
SciatiEase: from $49.99 a bottle120 capsules · 1, 3 or 6 bottles · free US shipping on 3 or 6 · 180-day guarantee
See packsAmounts05
Why do some pages list bigger SciatiEase amounts?
The brand home page shows higher figures than the panel.
It lists PEA 600 mg, R-ALA 300 mg, ALCAR 300 mg and benfotiamine 300 mg (SciatiEase order page); we follow the panel. Details on the supplement facts page.
Made of06
What is SciatiEase made of besides the actives?
A gelatin capsule, cellulose, vegetable stearate and silica.
Gelatin means the capsules are not vegetarian. Feverfew may bother people with a ragweed allergy (NCCIH, Feverfew).
Evidence07
Which SciatiEase ingredient has the best evidence?
PEA, though its trials were small and short.
Carnitine studies used 6 times the dose here or more (Rolim et al., Cochrane 2019). Keep taking prescribed medicine; see side effects.
FAQ08
SciatiEase ingredient questions
What are the active ingredients in SciatiEase?
PEA 500 mg, R-alpha lipoic acid 250 mg, acetyl-L-carnitine 250 mg, benfotiamine 200 mg, four B vitamins and a 50 mg blend of feverfew, passionflower, Chinese skullcap and oat straw.
What is SciatiEase made of?
Twelve active lines plus a gelatin capsule, microcrystalline cellulose, vegetable stearate and silica. Gelatin is not vegetarian.
What vitamins are in SciatiEase?
B2 25 mg, B6 20 mg, folate 500 mcg DFE and B12 1,000 mcg, all in active forms. Benfotiamine 200 mg adds a fat-soluble form of vitamin B1 (NIH ODS, Thiamin).
Which SciatiEase ingredient has been studied for sciatica?
Only PEA. One 3-week trial of 636 people with sciatic pain compared 300 mg, 600 mg and placebo (Keppel Hesselink, J Pain Res 2015). The other lines were studied mostly in diabetic nerve damage.
Are the SciatiEase ingredient doses high enough to matter?
Some are. PEA 500 mg falls inside the 300-1,200 mg trial range (Lang-Illievich et al., Nutrients 2023). Acetyl-L-carnitine at 250 mg is far below the 1,500-3,000 mg used in studies (Rolim et al., Cochrane 2019).
Could I be allergic to anything in SciatiEase?
Possibly. Feverfew is a daisy-family herb, so ragweed allergy is a concern (MSKCC, Feverfew). Ask your pharmacist.
Who wrote this09
Written and reviewed by
Pages built from the label, the brand pages and linked NIH, FDA, FTC, NICE and peer-reviewed sources.
Last updated . How we work: editorial standards and how we check reviews. This website is run by a licensed SciatiEase retailer, not by the manufacturer, SciatiEase Labs. We earn money when you buy through our order links.
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