One label line, two ingredients
AlphaPalm Blend: What the 750 mg in SciatiEase Contains
The AlphaPalm Blend is a 750 mg line on the SciatiEase panel made of 500 mg palmitoylethanolamide (PEA) and 250 mg R-alpha lipoic acid (R-ALA). Unlike the herb blend, both amounts are printed. PEA sits in the trial range, while the human ALA studies used a different, mixed form. No trial tested the two together.
Written by the SciatiEase label deskUpdated · 4 min read
The line01
What is the AlphaPalm Blend?
AlphaPalm Blend is the label's name for PEA plus R-ALA, 750 mg in all.
It is a branded blend name, not a separate ingredient. The panel prints the two parts: PEA 500 mg and R-alpha lipoic acid 250 mg. We found no other source that describes AlphaPalm.
That makes it more open than the 50 mg herb blend, where single amounts stay hidden (21 CFR 101.36 (eCFR)).
Against the studies02
How does the AlphaPalm Blend compare with study doses?
PEA is inside the studied range. R-ALA cannot be matched directly.
A review of 11 PEA trials covered 300 to 1,200 mg a day, with lower pain scores and no major side effects (Lang-Illievich et al., Nutrients 2023). A sciatica trial used 300 and 600 mg a day for 3 weeks (Keppel Hesselink, J Pain Res 2015).
For ALA, every human study used the mixed R and S form, and oral 600 mg a day was typical (Linus Pauling Institute, Lipoic Acid).
| Part | Panel | Studied |
|---|---|---|
| PEA | 500 mg | 300 to 1,200 mg a day (Lang-Illievich et al., Nutrients 2023) |
| R-ALA | 250 mg | 600 mg oral, mixed form (Linus Pauling Institute, Lipoic Acid) |
Cautions03
What should you watch with the AlphaPalm Blend?
Blood sugar is the main flag, from the lipoic acid half.
- ALA may lower blood sugar, so people on insulin or diabetes pills should tell their prescriber (Linus Pauling Institute, Lipoic Acid).
- Rare cases of insulin autoimmune syndrome, with repeated low sugars, have been reported with ALA (Vallianou et al., Metabol Open 2026).
- Possible side effects of ALA include nausea and rash (Linus Pauling Institute, Lipoic Acid).
- Long-term PEA safety data come from animals only (Nestmann, Food Sci Nutr 2017).
Keep taking prescribed medicine. A supplement never replaces it.
SciatiEase: from $49.99 a bottle120 capsules · 1, 3 or 6 bottles · free US shipping on 3 or 6 · 180-day guarantee
See packsGaps04
Is the AlphaPalm Blend proven together?
No study of the pair exists that we could find.
Each part has its own research. The label calls the formula research backed, but the FTC notes that single-ingredient studies may not support claims for a combination (FTC, Health Products Compliance Guidance). Compare with PEA for sciatica and the ingredient guide.
FAQ05
AlphaPalm Blend: specific questions
Is AlphaPalm a different ingredient from PEA?
No. AlphaPalm is the brand's name for a blend of PEA and R-ALA on the panel. The two are listed with their own amounts, so you can check each against trial doses.
How much PEA is in the AlphaPalm Blend?
500 mg per 4-capsule serving, which is two thirds of the 750 mg line. A bottle of 120 capsules gives 30 servings, so it holds 15,000 mg of PEA in all.
Is R-ALA the same as the alpha lipoic acid in studies?
Not quite. Human studies used the mixed R and S form (Linus Pauling Institute, Lipoic Acid). R-ALA is the form the body makes, so results from the mixed form may not carry over.
Does the brand home page list a different AlphaPalm amount?
It lists PEA 600 mg and R-ALA 300 mg (SciatiEase order page), which would total 900 mg. The panel prints 500 and 250, and this site follows the panel.
Can the AlphaPalm Blend lower blood sugar?
The R-ALA half may (Linus Pauling Institute, Lipoic Acid). If you use insulin or diabetes medicine, ask your prescriber before starting and watch glucose readings, never changing medicine on your own.
Who wrote this06
Written and reviewed by
Pages built from the label, the brand pages and linked NIH, FDA, FTC, NICE and peer-reviewed sources.
Last updated . How we work: editorial standards and how we check reviews. This website is run by a licensed SciatiEase retailer, not by the manufacturer, SciatiEase Labs. We earn money when you buy through our order links.
Keep reading
More about SciatiEase
Licensed SciatiEase retailer
Ready to try SciatiEase?
Look over your medicines first, then choose a pack. Three or six bottles ship free in the US and cost less per bottle, and the 180-day guarantee covers every pack.
- Secure checkout on the brand page
- 180-day guarantee
- Ships from the U.S.
